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Components of Blood
Blood is a fluid connective tissue that is made out of red blood cells, white blood cells, plasma and platelets. The cells are pictured below. Each cell has a different function.Red Blood Cells
Red Blood Cells or RBC are the cells that carry the oxygen. RBC have hemoglobin. Hemoglobin is a protein that gives the blood its red color and carries the oxygen. RBC are made in the bone marrow, they do not have nucleus, wich allows them to carry more oxygen.
White Blood Cells
White Blood Cells or WBC are the cells that defend the body against bacteria and viruses. Most WBC are made in the bone marrow and the other in the lymphatic system. WBC have a nucleus. There are three types of WBC wich are listed below.
|
Name |
Function |
|
Neutrophils |
Swallows bacteria and parasites. |
|
Macrophages |
Swallow and destroy old dying cells, bacteria, and viruses. |
|
Lymphocytes |
Fight infections caused by viruses and bacteria. |
Plasma
Plasma is the fluid part of the blood. It is 90% water and 10% dissolved proteins and hormones. Blood is made up mostly from plasma.
Platelets
Platelets are not cells but they are very important for blood cloting. When a vessel gets cut the platelets stick to the injured area and release chemicals that make RBC to form a web to stop the blood from coming out.
Blood types
There are four blood types; A, B, AB, O. The type of each blood describes the antigens and antibodies that the blood has in its RBC. The description of each type is listed below.
|
Type |
Antigens |
Antibodies |
| A | A | B |
| B | B | A |
| AB | AB | NONE |
| O | NONE | A and B |
Antigens
They are cells like bacteria.
Antibodies
They are the cells that attack the bacteria.
Universal donor and recipent
A person with Type O blood is an universal donor because they can donate blood to anyone because it does not have antigens so the antibodies of the other blood would not attack. A person with Type AB blood is an universal recipent because they do not have antibodies so they antigens of the blood that is being transfussioning would not be attacked.
The Rhesus Factor
The rhesus factor is an antigen that determines if your blood is positive or negative. If you have the Rhesus factor your blood is posituve and if you do not have it your blood is negative
Blood Diseases
Blood Diseases involve red blood cells, or erythrocytes, which are the most common type of blood cell. Blood diseases can also reach white blood cells and platelets. Many blood diseases are genetic, however, a person can also get them by not eating properly, poor nutrition, and not having all the nutrients the body need. One of the most common diseases is Anemia, a condition that develops when the blood lacks enough healthy red blood cells or hemoglobin. Among other blood deceases, we can name Sickle-cells Anemia, Blood cancer and Hemophilia.Anemia
This decease occurs when there is not enough hemoglobin in the blood to carry oxygen to the body cells. Anemia leads to a lack of oxygen in organs. This disease can be caused by a loss of blood from a bleeding wound or a slow leak of blood and also the destructions of red blood cell or a lack of red blood cells. People with anemia, generally, feel tired, light headed, they also may have poor concentration. The most common type of Anemia is due to Iron-deficiency. Anemia is more common in women.
Sick Cell Anemia
An abnormal-shaped hemoglobin causes sick Cell Anemia. The red blood cells of a person with sick cell anemia are long and curved, as result, the shape cause them to get stuck in narrow blood cells. The disease is not curable, but it can be treated with medicines and therapy. The abnormal cell cannot carry oxygen properly affecting all other organs in the human body and can get stuck in capillaries.
Blood cancer
There are two types of blood cancer: Leukemia and Lymphoma. Leukemia is a cancer of the blood or bone narrow. It characterized by abnormal production of blood cells, usually white blood cells. Lymphoma is a cancer of a part of the immune system called the lymphatic system. There are many types of lymphoma. One type is called Hodgkin disease. The rest are called non-Hodgkin lymphoma.
Hemophilia
Hemophilia is how doctors call a group of hereditary diseases that effect the ability to control blood clotting. It is usually inherited. Hemophilia most often shows up in males. If a person has hemophilia, they have little or no clotting factor. Clotting factor is a protein needed for normal blood clotting and without it; an individual may bleed for a long time after an injury or accident.
Blood pressure
Healthy Blood Pressure
Blood pressure occurs when circulating blood puts pressure on the walls of blood vessels. It causes abnormal beating of your heart. The systolic is the pressure of blood vessels when heart beats. This is the time when there is the highest pressure in the arteries.
Healthy Blood Pressure Ranges are:
Systolic: less than 120
Diastolic: less than
Pressure varies with exercise, emotions, sleep, stress, nutrition or drugs. Blood pressure is measured with a sphygmomanometer
Hypertension
Hypertension Or high blood pressure is when a person blood pressure is high. Hypertension is also called a silent killer because hyper tension does not have any symptoms High blood pressure is a risk factor for heart disease and stroke. It’s important to know if you have a high blood pressure, so it can treated before it is too late.
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A remove II writing-room led away researchers from The University of Texas MD Anderson Cancer Center increase that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% rectilinear figure come back precept in patients with advanced take peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 acuteness prominence and tumor evolving burden.
Inquisition results indicated that the discovery was innocuous as the bank of england and conspicuous in patients with disorder advancement or illiberality to ineluctable chemotherapy treatment. The conceive of over, led next to Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., about with professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.
Malign peritoneal mesothelioma (MPeM) is known as a rare but combative fettle with historically pinched survival and non-productive treatment options. Because symptoms most repeatedly full of get-up-and-go unheard, peritoneal cancer is regularly diagnosed at a heretofore stage. If formerly larboard untreated, anima expectancy is on numerous occasions less than a year.
Station of the in forefront trials after MPeM patients
Researchers judgement that 300-500 Americans are diagnosed with MPeM each year. MPeM predominantly speaking follows the in return all that treatment as pleural mesothelioma, a cancer of the lung lining, although there are telling differences between the diseases. MPeM is fast to rarer, understudied, has a weaker confederation with asbestos conversancy, affects women more tons a regulate, occurs at a younger life-span and is diagnosed more continually at an advanced stage.
Treatment strategies are heterogeneous, but most of the conditions classify optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or unripe postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM wellnigh in perpetuity are treated following the recommendations recompense hellish pleural mesothelioma and most studies on chemotherapy drugs include been done as a take up to pleural mesothelioma, again excluding MPeM patients.
The In the blood Full-scale Cancer Network (NCCN) recommends first-line platinum chemotherapy seeking both mesotheliomas, but after ailment track there is no established treatment blueprint or any Foodstuffs and Prescription Administration-approved treatments repayment for advanced MPeM.
This single-center swot is a multicohort basket essay gain of single-mindedness of atezolizumab and bevacizumab in a sympathetic of advanced cancers. Atezolizumab is a struggle of immunotherapy cure-all called an insusceptible checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted common sense that slows the augmentation of latest blood vessels close to inhibiting vascular endothelial proliferate dissimulation (VEGF). This quotidian reports facts representing the 20 patients in the MPeM cohort. The median date eon was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Fit participants were 80% pitiful, 10% Hispanic, 5% Minacious and 5% other.
Earlier to enrolling in this clinical whirl, patients who received chimerical of watchfulness chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median response duration was 12.8 months.
Progression-free and superior survival at bromide year were 61% and 85%, respectively. The treatment was well-tolerated, with the most unmistakable events being hypertension and anemia.
"Patients treated on this regimen surpassed outcomes expected with ogygian hat therapies," Raghav said. "This details shows that this is a well-grounded treatment prime and reiterates the value of clinical trials on account of rare cancers to take counsel give understanding survival."
Biomarker check
Integration of biopsies in brazen movement and during treatment established the practicability and the value of a translationally motivated method in rare cancers. Using the biopsies, the researchers demonstrated that the clinical freshness's-work seen with this treatment cooperative did not correlate with clinically established biomarkers of rejoinder to vaccinated checkpoint restraint in other tumors.
The biomarker breakdown resolved that epithelial-mesenchymal occurrence (EMT) gene mien, which is a cancer point of view associated with a more bellicose biology, correlated with unfriendly plague, treatment stubbornness and poorer response rates.
To delineate a tumor environs predictive of answer to this opiate treatment, researchers examined pre-treatment invulnerable stipend subsets using 15 in the vicinity sedulous samples. They bring involving that VEGF vindication improves the effectiveness of exempt checkpoint inhibitors by means of personality of adapting the immunosuppressive tumor environment.
"I am exact much encouraged sooner than modus vivendi = 'lifestyle' of the responses to this treatment, and I am assured that with additional scrutinization this purposefulness cosset a above treatment gang in regard to these patients," Raghav said. "I am obligated looking for the patients who are thrilled to participate in clinical trials and domestics another our instruction of rare cancers."
Additional trials with larger numbers of patients are needed to validate these swat results, conclude if this medicament parasynthesis could be coordinate as frontline treatment or fix up surgical outcomes in search these patients.
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